AIMP1 and pulmonary emphysema: Also, targeting the proapoptotic protein EMAPII via antibody neutralization significantly reduced the development of cigarette-smoke-induced emphysema despite prior, concurrent, and subsequent exposure of the animals to cigarette-smoke, suggesting EMAPII could be a therapeutic target in this kind of chronic obstructive lung disease.56 Summing up, the pathobiology of angiogenesis and vascular remodeling in COPD is still not fully understood.