VEGFA and neoplasm: Numerous studies show that a high tumor expression of VEGF189 is significantly correlated with large tumors, advanced clinical stage, and systemic metastasis, and represents also an independent prognosis factor in colorectal, renal cell, and non-small-cell lung cancer.23 Several lines of evidence indicate that tumor angiogenesis and tumor growth is suppressed when VEGF signal transduction is inhibited.24, 25 Such inhibition of VEGF signaling is also able to prevent metastases as a result of reduced contact between tumor cells and the capillaries.26