Other cytokines partake in angiogenesis, like basic-fibroblast growth factor (B-FGF) and platelet-derived endothelial cell growth factor (PDGF).4 Their impact is considered less important then VEGF but especially B-FGF is involved in angiogenesis in lung cancer.29 In contrast to VEGF, B-FGF requires basement membrane proteolysis or cell damage for its release and binding to multiple cell targets. This evidence concerns the gene FGF2 and lung cancer.