MTOR and differentiated thyroid carcinoma: Our group also found in papillary thyroid carcinoma (that also presents frequent mutation in BRAF gene) an increased activation of mTOR pathway in BRAF mutated PTC, and in vitro transfection of BRAFV 600E disclosed a positive association between BRAF (over)expression and mTOR pathway activation (Faustino et al., 2012).