MTOR and uveal melanoma: However, neither GNAQ wild-type nor mutated forms, lead to an increase in mTOR pathway activation, which is in line with the lack of association between GNAQ mutational status and mTOR pathway activation that we have reported in human uveal melanoma samples (Populo et al., 2011b) and also with the lack of alteration in AKT phosphorylation after loss of mutant GNAQ, already reported by others in uveal melanoma cell lines (Khalili et al., 2012).