MTOR and melanoma: Although all the cell lines displayed a significant reduction of S6 phosphorylation, which is considered a marker of mTOR inhibition (O’Reilly & McSheehy, 2010), cell lines harbouring a BRAFV 600E mutation (A375 and G361) displayed significant higher growth rate inhibition after RAD001 treatment than the other melanoma cell lines harbouring GNAQQ209L (92.1 and OMM2.3), or BRAFwt and GNAQwt (BLM, Mewo, OMM1 and Mel285) cell lines.