AKT1 and brain ischemia: Recent studies show that bothneuron-specific PHD2 knockout and PHD2 inhibitor treatment are effective in reducingtransient cerebral ischemia-induced brain damage via activating HIF-1α [17,18].Notably, baicalein can inhibit PHD2 activity by direct binding to the enzyme activesites [9], but whether its activation ofprosurvival PI3K/Akt signaling in neurons also contributes to the HIF1α target geneinduction remains undetermined.