IL1B and hemorrhage: N-benzyl-oxycarbonyl- Val Ala Asp-fluoromethyl ketone (Z-VAD-FMK), a caspase inhibitor, was shown to reduce the cerebral vasospasm on Day 2 after SAH in a rabbit single-hemorrhage model, which is associated with a decrease in the IL-1b release into the cerebrospinal fluid and the levels of caspase-1 and IL-1b in macrophages infiltrating into the subarachnoid space [27].