GPC3 and Autoimmunity: We have previously demonstrated the antigenicity of GPC3, and that the HLA-A*24:02-restricted GPC3298–306(EYILSLEEL) peptide and the HLA-A*02:01-restricted GPC3144–152(FVGEFFTDV) peptide can induce GPC3-reactive CTLs without inducing autoimmunity(17–21).