PIK3CA and ovarian carcinoma: Other molecules involved in the downstream signaling pathway of the Ang/Tie2 receptor include the PI3K protein, involved in the PI3K/Akt pathway, and also proteins such as Protein Kinase B, MAPK/Erk molecules, and also molecules of the Ras pathway [135,138], and these molecules may possibly, also, be involved in the downstream signaling of the Tie2 receptor in ovarian cancer.