VEGFA and neoplasm: Although in the normal ovary, Tie2 localization may indicate communication between the extracellular matrix and the endothelial cells, in mouse ovarian tumor models Ang-2 is mainly expressed in endothelial cells and the tumor stroma and its expression levels correlate with those of VEGF, therefore proposing a synergistic effect of the two molecules in ovarian cancer angiogenesis [137].