Two other results have confirmed the Dhh1 function in Cth2 AMD: first, yeast two-hybrid assays have revealed an in vivo interaction between the carboxy-terminal domain of Dhh1 helicase and the Cth2 RNA-binding protein; second, mRNA half-life experiments have established that Dhh1 contributes to SDH4 mRNA destabilization under low Fe conditions [41]. Here, SDHD is linked to age-related macular degeneration.