We also demonstrate that parvovirus H-1PV infection of colon carcinoma cells can enhance NK-cell-mediated killing of these cells, and that the cytotoxicity of NK cells towards mock- and H-1PV-infected colon carcinoma cells is mediated mostly by a combination of natural cytotoxicty receptors, namely NKp30, 44, and 46. Here, NCR3 is linked to colon carcinoma.