APOE and atherosclerosis: Indeed, in apoE−/−mice (a model of human atherosclerosis), FcγRs appear to be important for the clearance of LDL-containing IC and apoE−/− mice deficient for the activating γ chain of FcγRs show less development and progression of atherosclerosis than apoE−/− mice which possess the γ chain of FcγRs [59].