Babaei-Jadidi R et al. reported that accumulation of DEK and loss of epithelial TPM may contribute to the oncogenicity of FBXW7 mutation in both human colorectal cancer and in the ApcMin/+/Fbxw7ΔG mouse intestine, which is indicative of possible roles for DEK and TPM in colorectal tumorigenesis. The gene discussed is DEK; the disease is colorectal cancer.