Yang et al. confirmed that in WNK4 knock-in mice, the NCC present in the cell membranes of the luminal surface cells of the distal tubule is excessively phosphorylated owing to a WNK4 mutation, resulting in hypertension due to abnormal electrolyte/acid–base equilibrium and increased circulating blood volume[3]. This evidence concerns the gene WNK4 and Hypertension.