KIT and gastrointestinal stromal tumor: Since imatinib is less effective against GIST without KIT or PDGFRA mutation [33], and initial studies suggest that sunitinib treatment rarely results in objective responses in GIST [34,35], debulking surgery remains a recognized standard practice in the case of local progression because such procedure could prolong survival of patients who are resistant or insensitive to imatinib treatment [36].