In women with breast cancer or men with prostate cancer, the application of hormone deprivation therapies (aromatase inhibitors for post-menopausal women and gonadotropin releasing hormone [GnRH] agonists, anti-androgens, or orchiectomy in men) have dramatically improved cancer-related survival and reduced cancer-related recurrence [39-42]. The gene discussed is GNRH1; the disease is Familial prostate cancer.