For instance, KM1334 neutralizing antibodies targeting the FGF8 isoform b significantly hinder FGF ligand-mediated signaling in mammary tumorigenesis [169] and FGF8b-expressing clinical prostate cancers [170] in addition to, inflammatory responses and bone damages in rat model of rheumatoid arthritis [169–171]. Here, FGF8 is linked to Familial prostate cancer.