As shown in Table II, human colon cancer cells (HRT-18 and HT-29) were with loss of imprinting of IGF2 gene (LOI), and the human colon cancer cells (HCT-116), breast cancer cells (MCF-7) and human gastric epithelial cells (GES-1) were maintenance of imprinting of IGF2 gene (MOI each). The gene discussed is IGF2; the disease is breast carcinoma.