The therapeutic potential of a vector carrying the E1A gene driven by enhancer-DMD-H19 promoter complex was tested both in HRT-18 and HT-29 human ileocolon cells (LOI of IGF2), HCT-116 human ileocolon cells (MOI of IGF2) and MCF-7 human breast cancer cells (MOI of IGF2) and GES-1 human gastric epithelial cells (MOI of IGF2). The gene discussed is IGF2; the disease is breast cancer.