Recent research found that NDRG1 is upregulated in gastric, colon and pancreatic cancer cells through demethylation of the CpG loci in the promoter region [14,15], suggesting that the epigenetic regulation mechanism plays an important role in activating NDRG1 expression during cancer progression and gives cancer cells a changeable trait. This evidence concerns the gene NDRG1 and familial pancreatic carcinoma.