These questions include: (i) how CD14 initiates the NFAT signaling pathway and mediates the endosomal TLR4 re-localization in response to LPS; (ii) how CD14 contributes to host protection or, vice-versa, is deleterious depending on the type of infection; (iii) how CD14 and possibly the CD14/NFAT pathway regulate metabolism and lipid accumulation; (iv) what is the role of CD14 expressed by non-hematopoietic cells? The gene discussed is CD14; the disease is infection.