Moreover, in addition to the functions in innate immunity (Ostuni et al., 2010), a more general role for CD14 in regulating metabolism, insulin resistance, and obesity is emerging (Johnson et al., 2004; Roncon-Albuquerque et al., 2008; Fernandez-Real et al., 2011). The gene discussed is CD14; the disease is obesity due to melanocortin 4 receptor deficiency.