Given the capacity of CD14 to initiate the NFAT pathway, this observation calls for an evaluation of the role of the CD14/NFAT signaling pathway in the control of obesity and insulin resistance once induced by LPS in hematopoietic cells and/or in non-hematopoietic cells including adipocytes. Here, CD14 is linked to obesity due to melanocortin 4 receptor deficiency.