These types of therapies can include cytokines such as IL-2, immunostimulatory agents such as bacterial DNA, agonists and antagonists of key immunoregulatory molecules such as CD40 or PD-1, inhibitors of key enzymes such as cyclo-oxygenase or IDO, and vaccine strategies capable of encompassing the broad array and heterogeneity of tumor antigens such as syngeneic whole cell vaccines and in situ vaccines. Here, CD40 is linked to neoplasm.