FOXP3 and Autoimmunity: In this context, we have recently demonstrated that the FOXP3 expression in liver is positively correlated with the intensity of liver inflammation along with a specific pattern of mRNA expression of the apoptosis mediators FAS, FASL, and TRAIL, irrespective of the cause of tissue damage (viral, toxic, autoimmunity), suggesting that might represent a bystander effect and not a causative event of chronic inflammation (16).