Certain diagnoses: rheumatoid arthritis vs. other types of arthritis (Broekmans et al., 2009), combined subtype in ADHD, vs. inattentive or hyperactive subtype (Charach and Gajaria, 2008P), disease group (HIV, arthritis, GI diseases, and cancer vs. other) (DiMatteo, 2004b), disease group (diagnosis other than personality disorder and substance abuse, in depression) (Pampallona et al., 2002)Estrogen receptor positive (in breast cancer) (Ruddy et al., 2009). The gene discussed is ESR1; the disease is substance abuse.