Moreover, mutations in GIRK2 subunit reduced LTP and increased LTD in hippocampus (Sago et al., 1998; Siarey et al., 1999; Luscher and Slesinger, 2010) and it is especially relevant in Down syndrome, where cerebral Aβ accumulation is greatly accelerated and leads to invariant early-onset AD neuropathology (Lott and Head, 2005; Moncaster et al., 2010; Cooper et al., 2012). The gene discussed is KCNJ6; the disease is Down syndrome.