IGHE and asthma: In a cross-sectional study of asthmatic children in Costa Rica between the ages of 6 and 14 years, higher levels of vitamin D were associated with reduced asthma exacerbations as determined by reduced odds of hospitalizations or emergency department visits (OR = 0.05 95% CI 0.004, 0.71; p = 0.03), as well as lower serum IgE, eosinophil counts and inhaled steroid use [54].