There is abundant experimental evidence that urokinase-type plasminogen activator (uPA) is a multifunctional serine protease which possesses mitogenic, chemotactic, adhesive and migratory properties and thus plays an essential role in the process of tumor cell metastasis, aortic aneurysm, and multiple sclerosis [1,2,3,4,5,6,7,8]. The gene discussed is PLAU; the disease is aortic aneurysm.