MCAM and neoplasm: For example, MUC1 induces T cell apoptosis and increases invasiveness, MUC18 has been implicated in tumour angiogenesis, MUC2 enhances colon cancer metastasis to the liver, although it appears to inhibit initial neoplasia, MUC8 is up-regulated in metastatic medulloblastoma, and MUC3B is up-regulated in intestinal metaplasia [7].