AR and breast carcinoma: As for posttranscriptional modification, Yeap and colleagues demonstrated that AR mRNA stability is a major determinant of AR gene expression in prostate and breast cancer cells [48] and identified several RNA-binding proteins including HuA, CP1 and CP2 which bind to a highly conserved UC-rich region of 3′-UTR of AR mRNA and affect stabilization of AR mRNA [49].