VCAM1 and atherosclerosis: Therefore, one possible mechanism for ameliorating atherosclerosis is the down-regulation of pro-atherogenic molecules such as E-sel, ICAM-1, VCAM-1 and MCP-1.Besides, in the inflammatory progress of atherosclerosis, activation of endothelial cells and mactophages leads to the release of various kinds of cytokines, chemokines, and growth factors, which in return regulate the continued and advanced accumulation and migration of leukocytes, thus induce further inflammation [2].