IL6 and Miyoshi myopathy: To further explore the contact-independent induction of MM proliferation by Eos, we first tested whether the active soluble Eos-derived molecule(s) was IL-6 and/or APRIL, as each has been shown to be produced by many other cell types within the BM PC niche and to support the survival and proliferation of normal and malignant PCs, respectively.[6], [8], [11], [27], [28] However, our results indicated that the growth-promoting activity of Eos supernatants is not a result of IL-6 or APRIL prompting us to consider other soluble molecules.