Furthermore, immunoreactivity for kininogen-1 was found in the cytoplasm of ACA and CRC cells (Fig. 3 A–C), and the expression level of kininogen-1 was significantly higher in CRC tissues than that in ACA tissues or normal mucosa (48.39% vs. 15.58% vs. 0%, P<0.05; Fig. 3D). The gene discussed is KNG1; the disease is colorectal carcinoma.