As shown in Fig. 2Aa, the area under the ROC curve (AUC) for serum kininogen-1 in association with a diagnosis of ACA was 0.635 (95% CI: 0.551–0.719, P = 0.003), while the AUC associated with a diagnosis of CRC was 0.706 (95% CI: 0.635–0.777, P = 0.000; Fig. 2Ac). Here, KNG1 is linked to colorectal carcinoma.