While cytoplasmic accumulation of kininogen-1 was found to negatively correlate with tissue histology for ACA patients (rs = -0.250, P = 0.029), it did not correlate with tumor location, tumor size, or grade of intraepithelial neoplasia (all P>0.05, details in Table S2). Here, KNG1 is linked to intraepithelial neoplasia.