For examples, during the period from 2000 to 2008, the Taiwan NHI program only reimbursed IBT for CHC patients who had a histologic confirmation of chronic hepatitis, at least mild fibrosis, and serum alanine aminotransferase (ALT) levels at least twice the upper limit of normal on two occasions within 6 months before the initiation of treatment. The gene discussed is GPT; the disease is chronic hepatitis.