Fourth, the levels of inflammatory markers (e.g., C-reactive protein), cytokines (e.g., Interleukin-6) and adipokines (e.g., Leptin) might be also influenced by the supplementation of grape polyphenols, because recent study has indicated grape polyphenols might improve the inflammatory status in patients with cardiovascular disease [51]. The gene discussed is LEP; the disease is cardiovascular disorder.