Among them, the autosomal dominant tumor necrosis factor receptor (TNFR)-associated periodic syndrome (TRAPS) has been associated with mutations in TNFRSF1A[1], a widely expressed gene encoding the 55 kDa TNF receptor (also known as TNFR1 or p55). This evidence concerns the gene TNFRSF1A and TNF receptor 1-associated periodic fever syndrome.