Although not always consistent, findings for hyperactivity of the HPA axis as indicated by increased cortisol and adrenocorticotropin-releasing hormone (ACTH) responses to a psychological stress task [5] and to the dexamethasone/corticotropin-releasing factor (Dex/CRF) test [3], hypersecretion of salivary cortisol over the daytime hours [6], and enhanced cortisol awakening response (CAR) [7] among individuals with early life stress independent of psychosis diagnosis have been observed in an emerging body of investigations. Here, CRH is linked to psychotic disorder.