RYR1 and centronuclear myopathy: Indeed, mutations in the RYR1 gene can lead to several clinical phenotypes: Malignant hyperthermia susceptibility including King-Denborough syndrome (MHS, pharmacogenetic disorder of skeletal muscle, MIM#145600), Central Core Disease (CCD, MIM#117000), as well as some forms of Multi minicore disease (MmD, MIM#255320), Centronuclear myopathy (CNM, MIM# 160150), congenital fiber type disproportion (CFTD, MIM#255310) and other rare atypical myopathies (see [3] for review).