The stratified analyses of the associations between OS and the polymorphisms of the GST and DNA-repair alleles based on the TNM stage showed that both stage II/III and stage IV CRC patients with the XPD Gln allelic variants didn't have a significantly poorer OS, with HRs of 1.43 (P = 0.085) and 1.31 (P = 0.264), respectively, compared to patients with XPD Lys/Lys genotype (Table 4). This evidence concerns the gene ERCC2 and colorectal carcinoma.