TP53 and cancer: The median age of onset (±standard deviation) of first cancer in the germline TP53 probands was 33±14yrs compared to 48±18yrs in non-carriers (Student’s unpaired 2-tailed t-test P = 1.19×10−3), and the median age at first sarcoma was 36±17yrs vs 50±18yrs (P = 4.33×10−3) (Table 3).