In that way, we cannot relate this specific effect with the described effects of azurin regarding its binding and modulation of p53 pro-apoptotic activity.This specificity shown for azurin effect on cadherins is very interesting, since P-cadherin expression is correlated to increased cell motility, cell migration and invasion [6], only in cell systems that are also positive for E-cadherin expression; in highly invasive melanoma, which lacks the expression of E-cadherin, P-cadherin expression is able to induce cell-cell contacts and decrease invasion [5], [20], [21]. This evidence concerns the gene CDH1 and melanoma.