This result is interesting, since soluble forms of classical cadherins have been associated with malignant effects [23]: soluble E-cadherin was associated with increased invasion and with the inhibition of normal E-cadherin-dependent cell-cell aggregation [24], and higher levels of soluble P-cadherin were found in nipple aspirate fluids of breast cancer patients than in healthy women [25]. This evidence concerns the gene CDH1 and breast cancer.