In order to achieve this goal, three different breast cancer cell lines expressing different levels of P-cadherin and with different p53 status were used: MCF-7/AZ.Mock and MCF-7/AZ.Pcad, which present a p53 wild type function, and SUM149, which constitutively overexpresses P-cadherin and shows a mutant form of p53. The gene discussed is CDH3; the disease is breast cancer.