In obese or hyperglycemic type 2 diabetic patients, circulating levels of AEA and 2-AG are increased and elevated levels of 2-AG are found in visceral adipose tissue [2], [5], [6], while hepatic Cb1r activation leads to impaired insulin sensitivity as well as reduced insulin clearance in mice [7]. The gene discussed is INS; the disease is type 2 diabetes mellitus.