Our current study demonstrates that alcohol and endocannabinoids, two major factors shown by various studies to deregulate liver function that results in various metabolic syndromes, elicits a stress-response leading to activation of Crebh and alters expression of multiple genes involved in bile acid metabolism, thereby suggesting a link between alcohol and cannabinoid receptor signaling with ER stress and deregulated bile acid metabolism in the liver (Fig. 6C). The gene discussed is CREB3L3; the disease is metabolic syndrome.