ESR1 and breast carcinoma: Excecpt for clinical characteristics, recently, a genome-wide nested case-control study had identified four SNPs in tight LD on chromosome 14 that were associated with MS-AEs in women receiving AIs for resected early-stage breast cancer [23].In this study, two ESR1 SNPs, rs2234693 and rs9340799 in the first intron were associated with AIs-related MS-AEs.