AKT1 and malignant colon neoplasm: Addtionally, the fact that CDF modulation of miR-21-PTEN-Akt axis could be observed in chemo-resistant colon cancer cells that are highly enriched in CSCs/CSLCs suggests that this novel analog of curcumin could also be therapeutically effective for recurrent cancer, which is known to be resistant to conventional chemotherapy [14].