However, HF mice treated with enalapril, in addition to a reduction in both energy intake and BM, showed improved glucose tolerance and insulin sensitivity (as indicated by the improvement of fasting plasma insulin and glucose, as well as higher serum adiponectin), enhanced islet remodeling, normalization of both alpha and beta cell masses, and sustained beta cell function (Pdx1 and GLUT2 expression), compared to the HF group. Here, INS is linked to hydrops fetalis.