Previously, in the course of our studies examining the role of histamine and histamine receptors in experimental autoimmune encephalomyelitis (EAE) – often used to model aspects of these essentially conflicting hypotheses – we identified histamine H3 receptor (Hrh3/H3R) as a gene that potentially unites these opposing theories functionally [11]. This evidence concerns the gene HRH3 and experimental autoimmune encephalomyelitis.