GZMB and metabolic syndrome: Presence of the D401H mutation may predispose individuals to an adverse metabolic profile and increase the risk of metabolic syndrome-related atherosclerotic cardiovascular disease.21 The GRβ polymorphism A3669G, in the 3′ untranslated region, results in enhanced expression of the dominant-negative GRβ and is associated with favorable metabolic parameters.22 However, the relationship between the GR gene and cardiovascular disease varies substantially among populations because the frequency and effects of polymorphisms differ greatly by race.6