Further study of the panel of annexin I, PGP9.5, and 14-3-3 theta antigens found that reactivity against PGP 9.5 was not significant, while annexin I, 14-3-3 theta, and a novel lung cancer antigen, LAMR1 showed significant reactivity for prediagnostic sera [67]. The gene discussed is ANXA1; the disease is lung carcinoma.