TP53 and Familial prostate cancer: Finally, reduced expression of WT1 and TP73 proteins may have major implications for tumorigenesis: WT1 is a transcription factor that has been shown to regulate growth and induce apoptosis when overexpressed in prostate cancer cells [44], and p73 is a p53-family protein that is key to apoptosis and growth arrest in human prostate cancer cells [45].