RELA and malaria: In addition, the expression of NF-κB p65 in the intravascular leukocyte in the CM brain tissue is consistent with a previous report that demonstrated that the activation of NF-κB p65 in the circulating peripheral blood mononuclear cells (PBMCs) of malaria patients could be due the suppression effect of high levels of interleukin (IL) -10 [31].