CD8A and myeloid sarcoma: The demonstration that mixed polyfunctional (type-1 and -17) CD8+ TEM cells specific for apoptotic T cell-associated self-epitopes are recruited in the CSF of MS patients and are associated with the clinical score of disease disability, suggests that apoptotic self-antigen-specific T cells with strong inflammatory potential largely expand at the level of the inflammatory site, and may contribute, through the production of high levels of inflammatory cytokines, to MS immunopathology.