In particular, both the median number of IFN-γ spots formed by CD8+ TEM cells from all MS patients or HDs in response to the single peptide pool (responsiveness) (Figure 1A), and the sum of IFN-γ spots formed in response to the total peptide repertoire by a single patient or HD (magnitude) (Figure 1B) were significantly higher in MS patients than in HDs. This evidence concerns the gene CD8A and myeloid sarcoma.