For examples, 14-3-3 proteins (14-3-3 protein epsilon, 14-3-3 protein beta/alpha and 14-3-3 protein zeta/delta) in cluster 1, play roles in cell survival, cell proliferation, anti-apoptosis and anti-tumor suppression by activating ERK/MAPK signaling pathway and the mitochondrial apoptotic machinery [34-37]. Here, YWHAE is linked to neoplasm.