Cisplatin activates acid sphingomy-elinase, followed by production of ceramides, leading to CD95 redistribution in lipid rafts and thereby apoptosis of human colon cancer cells, so its chemosensitization of cancer cells to Doxorubicin could also be acid sphin-gomyelinase/ceramide-dependent [30,31]. This evidence concerns the gene FAS and malignant colon neoplasm.