Currently, the diagnosis of pSS is based on the following: high titers for anti-SS-A/Ro, SS-B/La, and recombinant Ro-52 antibodies and rheumatoid factor; elevated IgG and IgA; accelerated ESR; decreased exocrine glandular function; no trace of other autoimmune or infectious disease; and the revised classification criteria for Sjögren’s syndrome proposed by the American-European Consensus Group [21]. Here, TRIM21 is linked to peeling skin syndrome.