ERBB2 and neoplasm: TF overexpression in malignant tumour cells seems to be directly related to oncogenic events such as the presence of the mutant oncogenes K-ras, EGFRvIII (epidermal growth factor receptor variant III) and HER-2 (human epidermal growth factor receptor 2), as well as the loss of the tumour suppressor genes p53 and PTEN (phosphatase and tensin homologue) [20–22].