F10 and neoplasm: Furthermore, the role of coagulation activation in tumour cell dissemination is supported by the antimetastatic effect of several anticoagulants, including the thrombin inhibitor hirudin [113,120]; and FXa inhibitors, such as NAP5 (Nematode Anticoagulant Protein 5) [121] and ACAP (Ancylostoma caninum anticoagulant peptide) [122].