In vitro and in vivo studies have demonstrated, for example, that the intracellular signalling promoted by thrombin, through the proteolysis of PAR1 in tumour and endothelial cells, elicits a proangiogenic process that is associated with VEGF production and signalling, as well as the secretion of MMPs (matrix metalloproteases) [47–49]. Here, VEGFA is linked to neoplasm.